Clinical Study on Alternaria spores sensitization.
Allergol Immunopathol (Madr). 2000 Mar-Apr;28(2):71-3.

Negrini AC, Berra D, Campi P, Cinti B, Corsico R, Feliziani V, Gallesio MT, Liccardi G, Loreti A, Lugo G, Marcucci F, Marcer G, Minelli M, Nardi G, Piu G, Passaleva A, Pozzan M, Puccinelli P, Purello D’Ambrosio F, Venuti A, Zanon P.
Servicio de Alergología, Ospedale S. Martino, Génova, Italia.

BACKGROUND: sensitization to fungi spores is often associated with sensitization to other allergens and so it is difficult to estabilish the exact cause of illness. OBJECTIVE: the aim of the study was to evaluate a group of patients monosensitized to Alternaria and to establish the prevalence, periodicity and clinical profile of this kind of sensitization. METHODS: 37 subjects who were monosensitized to Alternaria (prick-test positive), according to a previous epidemiological study were evaluated. Clinical symptoms and the period of their occurrence were taken into consideration as well as immunological parameters (RAST). RESULTS: 20 patients (over 50%) included in the study proved to be affected by asthma associated with other allergic symptoms and 22 patients (60%) presented perennial symptoms. The RAST carried out on 34 monosensitized subjects proved positive in 11 and negative in 23. CONCLUSIONS: Alternaria sensitization is characterized by a perennial periodicity with severe respiratory symptoms (asthma) which occur primarily in children. Prick test is preferable to and more reliable than RAST as a diagnostic test.

PMID: 10804097 [PubMed - indexed for MEDLINE]